Abstract
ABSTRACT The effect of different extracts of elder (Sambucus nigra L.) flowers on biochemical reactions in rats before and after CCl4-in-duced hepatotoxicity was examined. Administration of elder flowers impaired antioxidant defense mechanisms, particularly by depletion of liver glutathione (GSH) content and reduction of activities of catalase (CAT) and peroxidase (Px). Rats treated with CCl4 had an expected increase in lipid peroxidation (LP) and a decrease in glutathione reductase (GSH-R), CAT and Px activity. Pretreatment of the rats with elder flower extracts before treatment with CCl4 amplified the CCl4-induced liver injury, increasing LP and reducing GSH content. Treatment with both CCl4 and flower extracts significantly increased the serum trans-aminases: glutamic pyruvic transaminase (SGPT) and glutamic oxalacetic transaminase (SGOT).
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
