In Vivo Antitumor Activity of Ethanolic Extract of Lepidagathis Pungens Nees Whole Plant

Abstract

Cancer is the most dreadful of all the diseases and is the major contributors to the mortality in the world. Out of all the population, almost 1.2 million patients die due to cancer and related problems. The rate and spread of cancer are wide and even in both women and men. It is presently as high as 3.5 million people who have cancer in India alone. There are many ways of treatment of cancer like the surgery, radiation therapy, cryosurgery and chemotherapy. A part of chemotherapy is the usage of a lot of chemicals and synthetic drugs. Due to the side effects of chemotherapy, patients often get symptoms due to the usage of drugs, and so the cancer treatment often is toxic. Because of this, herbal drugs are seemed to have no side effects, and non-toxic effects, and so this project deals with identifying the plant sources of the drugs that treat cancers effectively. The present study focusses on the extraction of the chemical constituents from Lepidagathis pungens whole plant and using the same to estimate the anti-tumour potential in EAC induced tumour induction method. The activity was tested in two doses 200 and 400 mg/kg of the extract. They showed a dose-dependent activity when estimated for the tumour parameters and other haematological measures like RBC, WBC counts. They showed similar activity when estimated for the antioxidant enzymes like SGOT, SGPT, Catalases, LPO and ALP levels.