Abstract
Background Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Thus, the present study aimed at evaluating the antiplasmodial activity of Terminalia brownii in Plasmodium berghei infected mice. Methods A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of T. brownii against P. berghei in Swiss albino mice. Results The in vivo acute toxicity test indicated that both extracts of T. brownii against p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (Conclusion The present study indicated that hydromethanolic and aqueous bark extracts of T. brownii possess a promising antimalarial activity, with higher effect exhibited by the hydromethanolic extract.T. brownii against
Highlights
Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden
Chemosuppressive Effect of the Plant. e 4-day chemosuppressive study revealed that the 80% methanol and aqueous extracts of T. brownii exhibited a significant inhibition of parasitemia (p < 0.001) in a dose-dependent manner compared to negative control (Table 1). e level of suppression revealed by 80% methanol extract at concentrations of 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/ day in the 4-day suppressive test was 32.7%, 47.1%, and 60.2%, respectively
Malaria remains a major public health problem in the world, which is responsible for death of millions of people, in sub-Saharan Africa
Summary
Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of T. brownii against P. berghei in Swiss albino mice. There is one species, P. knowlesi, that naturally infects macaques and has recently been recognized to be a cause of zoonotic malaria in humans [2, 3]. Malaria remains a major killer of children under five years, taking the life of a child every two minutes [1]. It is a severe disease in Ethiopia, where 75% of the land is malarious and more than 54 million people are vulnerable [4, 5]
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