Abstract
The anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous macerate of A. gummifera was most effective that reduced the fasting blood glucose with 62.7%. In addition, this extract restored the biochemical parameters of diabetic mice to normal.
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Highlights
Diabetes is a chronic disease characterized by insulin deficiency or resistance (OMS, 1999)
Thirty mice were divided into five groups: a) Nondiabetic; b) untreated diabetic; c) diabetic treated with aqueous macerate of A. gummifera; d) diabetic treated with methanol macerate of A. gummifera; e) diabetic treated with metformin (300 mg/kg)
No death was observed for mouse after being given aqueous and methanolic macerates of A. gummifera at a dose of 2,000 mg/kg
Summary
Diabetes is a chronic disease characterized by insulin deficiency or resistance (OMS, 1999). Type 1 diabetes is treated with insulin therapy, as for type 2 diabetes, which in addition to diet and lifestyle changes, is treated with oral anti-diabetic agents that have a beneficial effect on lowering blood glucose levels, but they have many adverse effects and contraindication that affect the quality of life of the diabetic patient (Group et al, 1986) Several plants such as Allium cepa (Campos et al, 2003), Gaultheria trichophylla (Alam and Saqib, 2017), Nigella sativa (Meddah et al, 2009), Olea europaea (Long et al, 2010), Origanum vulgare (Lemhadri et al, 2004), Salvia officinalis (Eidi and Eidi, 2009), Trigonella foenum-graecum (Hamza et al, 2012), Verbena officinalis (Sheyla et al, 2011) have been reported to have anti-diabetic effect. To confirm or refute this use, we have opted for a plant which is widely used in traditional Moroccan medicine for the treatment of several diseases such as epilepsy, psoriasis, ulcers and hemorrhage (Hammich et al, 2013; Bnouham et al, 2006). It is named Atractylis gummifera L., and in Moroccan dialect it is called Added or Chouk el Elk
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