Abstract
ObjectiveThe current study aimed at evaluating in Albino mice the analgesic, anti-inflammatory, and antioxidant effects of Achillea odorata; a medicinal plant commonly used in Algerian folk medicine to provide scientific basis for its use. MethodsThe biological tests were performed on aqueous extracts. Antinociceptive activity was estimated using acetic acid that induces algesia in mice. Anti-inflammatory activity was investigated using carrageenan-induced paw edema method and the antioxidant effect was performed using MDA, GSH, CAT and SOD estimations. ResultsThe study of the analgesic activity of the A. odorata polyphenolic extract showed a very potent analgesic activity with an ability to inhibit abdominal cramps similar to that of positive control. In addition, evaluation of edema inhibition percentage showed that plant extract has a significant anti-inflammatory activity. In addition, the extract has the ability to modulate the redox potential in vivo, induced by inflammation, which has been demonstrated by the determination of GSH, MDA, CAT and SOD. ConclusionsOur results suggest that A. odorata possesses potential antinociceptive, anti-inflammatory and antioxidant compounds which could be tested as drug candidates against oxidative and inflammation-related pathological processes.
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