Abstract
The Krueppel-type zinc finger gene family, characterized by its well-established C2H2 DNA-binding motif, is one of the largest eukaryotic gene families, with many members that are transcription factors (Turner and Crossley 1999). The KRAB (Krueppel-associated box) domain has been found in a subset of the C2H2 zinc finger family, in about 300 human genes. Since the KRAB domain displays strong transcriptional repressor activity when tethered to DNA (e.g., Margolin et al. 1995), the KRAB zinc finger proteins most likely comprise a class of transcriptional regulators. The KRAB domain, as well as the C2H2 modules, offer a great prospect for the generation of designer zinc finger proteins in biotechnological and therapeutical applications (Choo and Isalan 2000). The target genes and the exact biological roles of KRAB zinc finger genes are largely unknown.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
