Abstract
SUMMARYThrombosis and platelet aggregation were studied with the use of a modified Chandler apparatus as an in‐vitro technique. Fifty‐two healthy control subjects and 63 postoperative patients were investigated. There were three episodes of venous thrombosis in the postoperative group.Thrombus size and plasma fibrinogen levels were significantly greater in patients after operation than in control subjects. The plasma fibrinogen level, but not the thrombus size, was directly related to the extent of the operation. In both control and postoperative patients there was a significant correlation between thrombus size and the plasma fibrinogen levels. The total serum cholesterol level did not relate to thrombus size.The plasma thrombus formation time, but not the whole blood thrombus formation time, was significantly shorter in postoperative than in healthy subjects.Spontaneous platelet aggregation was markedly more frequent in postoperative subjects. This greater frequency could not be related to the elevated plasma fibrinogen levels.It was suggested that the findings with the Chandler apparatus might reflect a tendency to abnormal platelet aggregation which exists as a constitutional diathesis in some subjects after an operation.
Published Version
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