Abstract
AbstractEffective integration of synthetic fiber scaffold materials into connective tissues depends to a great degree on tissue attachment and ingrowth into the material. The authors have developed an experimental model that utilizes rat tendon explants to test the rates of cell colony formation on different types of synthetic fibers that are used as tendon and ligament scaffolds and for other medical uses. It was found that cell colony growth rates are linear on all 12 types of fibers tested. This agrees with the results of previous studies involving cell growth on synthetic fiber matrices. While most synthetic fibers showed similar colony growth rates, an overall trend was observed toward increased colony growth rates on fibers with relatively hydrophilic surfaces. One type of fiber that showed significantly increased colony growth rates was covalently coated with type I collagen. It was concluded that whereas most types of synthetic fibers had similar cell growth, a collagen coating can significantly enhance cell growth.
Published Version
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