Abstract
The study was aimed to evaluate the lipid peroxides blockage capability of carboxymethyl chitosan (CMCTS) from silkworm pupa. It was an experimental study. CMCTS was produced from silkworm pupa. CMCTS of silkworm pupa was subjected to be analysed the toxicity through Brine Shrimp Lethality (BSL) assay, antioxidant activity through DPPH assay, and lipid peroxides inhibitory capacity in human plasma through TBARS assay. The result of our screening indicated that 24 h of treatment of CMCTS had a low impact on the percentage of Artemia salina L. nauplii lethality. CMCTS of silkworm pupa provided a moderate antioxidant activity and a significant inhibitory effect on the lipid peroxide level of human plasma at a concentration of more than or equal to 10 mM. These results proved that CMCTS of silkworm pupa was non-toxic substance also can be used as an alternative antioxidant source.
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