In vitro Study for Antibiotic resistance of bacteria causing Urinary Tract Infection from Syrian adults

Abstract

Oral and parenteral antibiotics as amoxicillin-clavulanate, nitrofurantoin, cephalosporins, ttrimethoprim-sulfamethoxazole or fluoroquinolones were recommended to treat urinary tract infections UTIs. Resistance of uropathogens to antibiotic poses a serious concern worldwide. Therefore, this study aimed to evaluate the resistance in vitro of urine bacteria isolated from adult male and female patients with UTI to common used antibiotics in Syria. A total of 111 urine samples were collected in the laboratory. Firstly, the bacteria caused UTIs was identified. Then, the susceptibility of isolated bacteria to 16 antibiotic were evaluated with disc-diffusion method. As expected, the prevalence of UTI was higher in females than in males. E. Coli revealed the highest prevalence (70%), while Klebsiella showed the next highest rate (33%). 99.1% of urine bacteria were resistant to at least 2 antibiotics (110samples/111 samples). A high rate of resistance (≥ 50%) among isolated urine bacteria was observed to 10 antibiotics. Only 6 antibiotics has a rate of resistance below 50%. Amikacin and imipenem were the most active antibiotic with 0% resistance followed by gentamycin (11%). High overall resistance rates above 90% was found to cefexime (92%), cephalexin (93%), and cephalothin (95%). Due to the high resistance rates and Multi-antibiotic resistance, antibiotics sales should be regulated and not sale without prescription in Syria.