Abstract
The use of plant-based drugs against various human disorders have attained 
 global interest. Multicomponent essential oils are used to cure inflammation 
 related disorders. The present study was aimed to assess the anti 
 inflammatory potential of essential oil from Rosmarinus officinalis (EO 
 
 RO) using in vitro model of LPS-activated RAW macrophage cell lines. 
 
 EO-RO was hydro-distilled using Clevenger apparatus and evaluated first 
 for protein denaturation and proteinase inhibitory activities, followed by 
 assays for cyclooxygenase (COX) and lipoxygenase (LOX) activities in RAW 
 264.7 macrophage cell lines. The data was statistically analysed by one-way 
 analysis of variance. Dose-dependent inhibition was observed in protein 
 denaturation with 50 µg mL-1 EO-RO exhibiting a maximum inhibition of 
 67.77%. Similarly, proteinase inhibitory assay depicted 72.47% inhibition. 
 The COX and LOX activities showed increased inhibitions in dose-dependent 
 manner i.e. 25 to 100 µg mL-1 EO-RO displayed 58.72 and 75.33%; 28.58- 
 40.86% inhibition, respectively.
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