Abstract
Anti-idiotypic (anti-Id) antisera prepared against IgG from the cerebrospinal fluid of patients with multiple sclerosis were used to analyze culture supernatants of in vitro stimulated peripheral blood lymphocytes (PBL) from the patients. In the culture supernatants of pokeweed mitogen-stimulated PBL of four patients, idiotype-positive IgG was found. This finding provides additional evidence that the production of oligoclonal IgG in multiple sclerosis is not exclusively a feature of the central nervous system, but is also a systemic immunologic phenomenon.
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