Abstract
Corticosterone and aldosterone were demonstrated after in vitro incubation of adrenals from mice of the BALB/c, RIII, C3H and C57 strains. In addition, 11-dehydrocorti-costerone appeared to be present in small amounts in incubates of BALB/c and RIII adrenals. Cortisol was not positively identified in any in vitro incubates, nor was its presence detected in the peripheral plasma of 14- to 18-week-old BALB/c male mice. However, cortisol was present in small quantities in the plasma of young (4- to 6-week-old) BALB/c males. Quantitative studies of adrenal corticosterone production were made, although it was noted that the corticoste-rone-like material analyzed may also have included some 17-hydroxy, 11-deoxycorticosterone. These quantitative studies revealed that the adrenals of 3-month-old BALB/c, C3H and C57 males have a lower in vitro secretory activity than do those of 3-month-old females. Castration of BALB/c males resulted in enhanced adrenal activity. Except for C3H females, which show a relatively lo...
Published Version
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