Abstract
In the current investigation, screening of ethanolic extract obtained from Ficus lyrata leaves against pathogenic bacteria has been done in order to assess the antimicrobial activity aimed at detecting new sources of antimicrobial agents. The antimicrobial activity of the extract was determined using agar disc diffusion method. The antibacterial activity of leaf extract of F. lyrata was tested against human pathogenic bacteria — both Gram-positive (Staphylococcus aureus, methicillin-resistant S. aureus and Streptococcus pneumoniae) and Gram-negative strains (Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli). The results of this study provide evidence that the ethanolic extract of F. lyrata leaves has a mild antimicrobial activities, apparently, attributed to the presence of various secondary metabolites, which confirm the traditional use of this plant for the treatment of diseases caused by pathogens. These data allow us to suggest that the extracts of F. lyrata can be used to discover antibacterial substances for developing new pharmaceuticals to control clinically important pathogens responsible for severe disorders.
Highlights
Проведено скринінгове дослідження антимікробної активності етанольного екстракту, отриманого з листків Ficus lyrata, щодо патогенних мікроорганізмів з метою виявлення нових джерел антимікробних засобів
The results of antimicrobial activity of ethanolic extract obtained from the leaves of F. lyrata are presented in Figs 1 and 2
Our results showed that the ethanolic extract of F. lyrata leaves exhibited moderate activity against the Gram-positive bacteria (11.3 mm of inhibition zone diameter for Staphylococcus aureus) (Fig. 2), and the Gramnegative bacteria (10.3 mm for Escherichia coli)
Summary
Проведено скринінгове дослідження антимікробної активності етанольного екстракту, отриманого з листків Ficus lyrata, щодо патогенних мікроорганізмів з метою виявлення нових джерел антимікробних засобів. Результати дослідження свідчать, що етанольний екстракт листків F. lyrata виявляє помірну антимікробну активність, очевидно, обумовлену присутністю різних вторинних метаболітів, що підтверджує традиційне використання цієї рослини для лікування захворювань, викликаних патогенними мікроорганізмами. A number of Ficus species have been used as food source and due to their medicinal properties in both Ayurvedic and traditional Chinese medicine, especially among the inhabitants of the areas where these species are distributed. It is widely used for treatment of numerous diseases such as various disorders of the central nervous system, endocrine sys-. Many species within the Ficus genus have been encompassed by phytochemical and pharmacological investigations in previous years, there are many species that have not been studied and whose ethnobotanical relevance is yet to be investigated
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