In Vitro Screening of Anticancer Activity and Phytochemical of Connarus Wightii Medicinal Plant

Abstract

Due to the rising death rate from cancer worldwide, it is one of the biggest worries. Globally, medicinal plants have a significant impact on people's health. According to recent research, on the phytochemical analysis of medicinal plant in southern Tamilnadu, particularly in the southwest portion of the Kanayakumari district Thus, the primary goal of this study was to identify the phytochemical compounds, antioxidant properties and anti-cancer properties of medicinal plant connarus wightii. An analysis was conducted on the phytochemical make up of these extracts (chloroform, ethanol, and methanol). Additionally, the extracts from these plants were assessed for their anti-cancer properties. The most prevalent phytochemical components in the plants under investigation were found to be phenols, flavonoids, saponins, glycosides etc, According to recent research, plant extracts have anticancer action of connarus wightii As the result of anticancer investigation using the MTT assay, the test samples, chloroform, ethanol, and methanol extracts of connarus wightii , were strongly cytotoxic to human liver cancer (HepG2) cells with low IC50 values of 99.91, 158.12, and 47.42 µg/ml, respectively. They had an IC50 of less than 10 μg/ml against the cancer cell lines was investigated. This low IC50 suggests that crude extracts have potential as an anticancer drug. The significance of these identified plant species as a source of anticancer drugs was therefore emphasised by the current investigation.