Abstract
The characteristics of cancellous bone allografts as carriers of fusidic acid and teicoplanin are described. Particles of cancellous bone were compressed into a wire-mesh cylinder; five replicas were impregnated for one hour into fusidic acid; and another five for one hour into teicoplanin. Elution was estimated daily. Concentrations of fusidic acid and teicoplanin were determined by a microbiological assay. Both antibiotics were eluted at very high concentrations within the first days. Allografts impregnated in fusidic acid provided concentrations above 20 μg/ml for 20 days. Eluted teicoplanin after day 4 was below 10 μg/ml. It is concluded that cancellous bone allografts may allow adequate In Vitro elution of fusidic acid but not of teicoplanin. The latter results support their application in experimental models of osteomyelitis.
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