Abstract
Adiantum capillus veneris is a medicinally essential plant used for the treatment of diverse infectious diseases. The study of phytochemical and antimicrobial activities of the plant extracts against multidrug-resistant (MDR) bacteria and medically important fungi is of immense significance. Extracts from the leaves, stems, and roots of Adiantum capillus veneris were extracted with water, methanol, ethanol, ethyl acetate, and hexane and screened for their antimicrobial activity against ten MDR bacterial strains and five fungal strains isolated from clinical and water samples. Ash, moisture, and extractive values were determined according to standard protocols. FTIR (Fourier transform infrared Spectroscopy) studies were performed on different phytochemicals isolated from the extracts of Adiantum capillus Veneris. Phytochemical analysis showed the presence of flavonoids, alkaloids, tannins, saponins, cardiac glycosides, terpenoids, steroids, and reducing sugars. Water, methanol, and ethanol extracts of leaves, stems, and roots showed significant antibacterial and antifungal activities against most of the MDR bacterial and fungal strains. This study concluded that extracts of Adiantum capillus veneris have valuable phytochemicals and significant activities against most of the MDR bacterial strains and medically important fungal strains.
Highlights
Among foremost health problems, infectious diseases account for 41% of the global disease burden along with noninfectious diseases (43%) and injuries (16%) [1]
LM extract had a greater percentage of extractive value (35%) followed by REA (23.6%), SM (20%), LE (20%), RE (18%), RW (17.72%), SE (16.2%), RM (16%), SEA (12%), LW (12%), LEA (10.7%), LH (8%), RH (4.32%), SW (4%), and SH (2.75%) (Table 1)
The attention of researchers has been deviated by the increasing emergence of antibiotic resistance towards the medicinal plants in search of new, less toxic, and useful drugs
Summary
Among foremost health problems, infectious diseases account for 41% of the global disease burden along with noninfectious diseases (43%) and injuries (16%) [1]. In previous decades, the pharmacological companies have produced a number of new antibiotics, but even drug resistance has increased [5]. This situation has forced the attention of researchers towards herbal products, in search of development of better-quality drugs with improved antibacterial, antifungal, and antiviral activities [6, 7]. For the treatment of infectious diseases, different medicinal plants have been mentioned by many phytotherapy manuals because of their reduced toxicity, uncomplicated availability, and fewer side effects [11]. Numerous plants have been investigated for treatment of urinary tract infections, gastrointestinal disorders, and respiratory and cutaneous diseases [19]
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