Abstract
Dermatophytosis is one of the most common cutaneous fungal infections in India. Despite, quite a few numbers of antifungal agents available for treatment, the resistance to antifungals by dermatophytes is increasing day by day as seen by doctors in clinical practice. Itraconazole has shown good results in the treatment of dermatophytosis at doses of 100 mg once a day for 2 weeks and with 200 mg once a day for 7 days. However, there are multiple itraconazole brands available in India. In this study, five different itraconazole brands were evaluated in vitro for MIC values against clinical isolates of Trichophyton mentagrophytes and Trichophyton rubrum by two different methods i.e. broth dilution and disc diffusion tests. It was found that the Reference brand of itraconazole and the test brand of Itraconazole showed least MIC values as compared to other available brands.
Highlights
Infection of the hair, skin, or nails caused by a fungus dermatophyte is called as dermatophytosis
A large number of safe and effective antifungal agents are available for the treatment of dermatophytosis
The strains of T. mentagrophytes and T. rubrum (50 of each) used in this study were obtained from skin and nails of patients with dermatophytosis and onychomycosis
Summary
Skin, or nails caused by a fungus dermatophyte is called as dermatophytosis. Tinea pedis, and onychomycosis are common dermatologic diseases caused by dermatophytes.. Trichophyton rubrum and Trichophyton mentagrophytes, which cause infections of skin and nails, are two of the most commonly isolated dermatophytes. 2. A large number of safe and effective antifungal agents are available for the treatment of dermatophytosis.. A large number of safe and effective antifungal agents are available for the treatment of dermatophytosis.3 Antifungal agents such as triazoles (itraconazole, fluconazole), imidazole (ketoconazole), allylamine (terbinafine) and griseofulvin have been reported to have substantial activity in dermatophytosis. Itraconazole has shown good results in the treatment of dermatophytosis at doses of 100 mg once a day for 2 weeks and with 200 mg once a day for 7 days. Itraconazole has shown good results in the treatment of dermatophytosis at doses of 100 mg once a day for 2 weeks and with 200 mg once a day for 7 days. 5
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