Abstract
A qualitative study was performed of the capacity of hepatic microsomes of several wildlife species to metabolize 3,3′,4,4′-tetrachlorobiphenyl (TCB). Hepatic microsomes of species environmentally exposed to a polychlorinated biphenyls (PCBs): harbour porpoise ( Phocoena phocoena), harbour seal ( Phoca vitulina), common tern ( Sterna hirundo), and hepatic microsomes from species experimentally exposed to PCBs: eider duck ( Somateria mollissima), rainbow trout ( Salmo gairdneri), flounder ( Platichthys flesus), and Wistar rat, were incubated with 14C-labelled TCB ([ 14C]TCB). The mammals and birds were able to metabolize TCB at a rate that correlated with their ethoxyresorufin- O-deethylase (EROD) activity. No [ 14C]TCB metabolism was observed in the fish, despite elevated EROD activity in the trout. HPLC analysis of diisopropylether extracts of the microsomal incubations indicated the presence of 4-OH-, 5-OH-, and 6-OH-tetrachlorobiphenyl metabolites and a yet unidentified metabolite. The ratio of the different hydroxy metabolites formed varied for the various species.
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