Abstract
Transepidermal water loss (TEWL), as measured with an evaporimeter, was used as a rapid assessment of the integrity of the barrier properties of skin as part of in vitro skin permeation studies. For a variety of physical and chemical treatments (i.e. solvent extraction, surfactants, mechanical abrasion and bases) TEWL correlated strongly with tritiated water permeation at short times. In contrast to the tedious process of measuring permeation of a finite dose of tritiated water, TEWL is a rapid, convenient measurement, and it provides a clear indication of the time dependence of barrier integrity.
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