Abstract
Objective: The present study was aimed on formulation and evaluation of famotidine loaded niosomal formulation for in vitro and in vivo pharmacokinetic behaviour. Formulating it as niosomal formulation might be quite advantageous for prolonging the duration of pharmacological action and improved bioavailability.
 Methods: In the present study niosomal formulations were prepared by using most documented thin film hydration technique by using various grades of surfactants (span 20, 40, 60, 80) in varying ratios with cholesterol, negative charge inducer di cetyl phosphate (DCP) and drug famotidine. Suitable preformulation studies were conducted like identification of drug, excipient and drug compatibility study. The optimized drug loaded niosomes were characterized for size and morphology, polydispersity index, zeta potential, drug entrapment, in vitro release, in vivo study and stability study.
 Results: The results showed that the vesicles formed were spherical in shape, size ranging between 160.1 nm to 718.7 nm with zeta potential values indicating good stability and formulation containing span 60 (NMS7) showed the highest entrapment efficiency (73.234%). All the formulations showed prolonged release profile for more than 24 h with release kinetics better suited to zero order release pattern. In vivo study conducted on rabbits predicted a fourfold increase in pharmacokinetic parameter (area under curve)AUC and pharmacological action for more than 24 h as compared to free drug famotidine which showed its action only upto 12 h.
 Conclusion: Thus the famotidine loaded niosomal formulation may be considered as a very promising drug delivery system which could be successfully employed for prolonging the drug release and overcoming the drawbacks of conventional drug delivery systems.
Highlights
In recent years transporting the drug molecule to desired site in the biological system has become a very sophisticated area of pharmaceutical research, the role of novel drug delivery is limited to ease of administration and convenience but along with this it is needed to provide better pharmacological effect along with reduced side effects
The present research was conducted to build up an appropriate drug delivery system for delivery of famotidine
The characterization of the drug loaded niosomal suspension by Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed spherical shape with homogienety in all optimized formulations with polydispersity values well suited for oral drug delivery, zeta potential and vesicle size values reveal that the formulations have good stability with vesicle size in nano range
Summary
In recent years transporting the drug molecule to desired site in the biological system has become a very sophisticated area of pharmaceutical research, the role of novel drug delivery is limited to ease of administration and convenience but along with this it is needed to provide better pharmacological effect along with reduced side effects These novel carriers provide sustained drug release for prolonged duration resulting in enhanced therapeutic efficacy and minimized side effects [1]. Niosomes have shown advantages as drug carriers, such as being low cost and chemically stable as compared to liposomes [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
