Abstract
Fluoride release is important characteristic of glass-ionomer cements. Quantity of fluoride ions released from the glass-ionomer cements has major importance in definition of their biological activity. The objectives of this study were to define the quantity of fluoride ions released from the experimental glass-ionomer cements and to define the effect of fluoride ions released from the experimental glass-ionomer cements on their cytotoxicity. Concentrations of the fluoride ions released in the evaluated glass-ionomer cements were measured indirectly, by the fluoride-selective WTW, F500 electrode potential, combined with reference R503/D electrode. Statistical analyses of F-ion concentrations released by all glass-ionomers evaluated at two time points, after 8 and after 24 hours, show statistically higher fluoride releases from RMGICs: Vitrebond, Fuji II LC and Fuji Plus, when compared to conventional glass-ionomer cements: Fuji Triage, Fuji IX GP Fast and Ketac Silver, both after 8 and after 24 hours. Correlation coefficient between concentrations of fluoride ion released by evaluated glass-ionomer cements and cytotoxic response of UMR-106 osteoblast cell-line are relatively high, but do not reach levels of biological significance. Correlation between concentrations of fluoride ion released and cytotoxic response of NIH3T3 mouse fibroblast cell line after 8 hours is high, positive and statistically significant for conventional GICs, Fuji Triage and Fuji IX GP Fast, and RMGIC, Fuji II LC. Statistically significant Correlation coefficient between concentrations of fluoride ion released and cytotoxic response of NIH3T3 cell line after 24 hours is defined for RMGIC Fuji II LC only.
Highlights
The ability of glass-ionomer cements to release fluoride has been known for a long time [ ] and has been a significant factor in their increasing use in dentistry
Results obtained in this study showed that the rate of F— released from resin modified glass-ionomer cements (RMGICs) comparing with conventional glass-ionomer cements (GICs) at both time points were significantly higher
With the exception of Fuji II LC (GC Corporation), the present in vitro study demonstrated that the concentration of F— released by experimental RMGICs and GICs after the both and hours immersion had no significant effect on cytotoxic response of UMR- – osteoblast-like cells and NIH T mouse fibroblast cells
Summary
The ability of glass-ionomer cements to release fluoride has been known for a long time [ ] and has been a significant factor in their increasing use in dentistry. In view of the complex chemistry and physicochemistry of GICs and RMGICs differences in the processes responsible for the fluoride release can be expected [ ]. The objectives of this in vitro study were to define the quantity of fluoride ions released from the experimental glass-ionomer cements and to define the effect of fluoride ions released from the experimental glass-ionomer cements on their cytotoxicity
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