Abstract
The development of neuron cells in vagal nerve nuclei in medulla oblongata was studied in vitro in live newborns and stillborns from different cases. Morphological changes were studied in respiratory nuclei of dorsal motor centre (DMNV) and nucleus tractus solitarius (NTS) in medulla oblongata. The material from medulla oblongata was fixated in 10 micro buffered formalin solution. Fixated material was cut in series of 10mu thickness, with starting point from obex in +/- 4 mm thickness. Special histochemical and histoenzymatic methods for central nervous system were used: cresyl echt violet coloring, tolyidin blue, Sevier-Munger modification and Grimelius coloring. In immature newborns (abortions and immature) in dorsal motor nucleus of the vagus (DMNV) population stages S1, S2, S3 are dominant. In neuron population in vagal sensory nuclei (NTS) stages S1, S2 are dominant. In more advanced stages of development of newborns (premature), in DMNV stages S3 and S4 are seen and in NTS stages S2 and S3 are dominant. In mature phase of newborns (maturity) in vagal nucleus DMNV stages S5 and S6 are dominant, while in sensory nucleus NTS stages S4 and S5 are dominant. These data suggest that neuron population in dorsal motor nucleus of the vagus (DMNV) are more advanced in neuronal maturity in comparison with sensory neuron population of vagal sensory nucleus NTS. This occurrence shows that phylogenetic development of motor complex is more advanced than the sensory one, which is expected to take new information's from the extra uterine life after birth (extra uterine vagal phenotype).
Highlights
Synapse forming is the most important process during neurogenesis
In the beginning of the th month of foetal life many nerve fibres begin to take a white appearance due to myelin depositing, which is formed from repeated coiling of Schwan cells membrane around the axon
The stages of development of nerve cells in the population of nervus vagus nuclei are shown in the following figures (Figure - ): BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES 2008; 8 (4): 382-385
Summary
Synapse forming is the most important process during neurogenesis. Synaptic contacts are a product of interaction between endogenous factors (genetic) and exogenous factors (time and space). In the beginning of the th month of foetal life many nerve fibres begin to take a white appearance due to myelin depositing, which is formed from repeated coiling of Schwan cells membrane around the axon. Analysing the development of talamus nuclei in human foetus, in vitro, using Nissl coloring method and based on basophyllic level, nuclei methachromasia, cytoplasm coloring, nucleocytoplasmatic index and the occurrence of Nissl substance, nerve cell differentiation can be divided in stages ( , ). In this early stage cell nuclei are closed, round, with granular material, dense chromatin, basophilic cytoplasm which can’t be seen. The size of nuclei grows, nucleolus is visible in form of metachromatic granules, and basophilic chromatin disappears, while its residue goes in periphery.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call