Abstract
Objective: Gastrointestinal motility and functional motility disorders causing either delayed or accelerated gastric emptying (GE) may result in similar symptoms including nausea, vomiting, early satiety, fullness, bloating, and abdominal discomfort or pain. Hence, it is important to evaluate patients for both rapid and delayed GE in the same test. The gold standard technique to measure GE is scintigraphy by radiolabeled test meals. The aim of this study was to test alternative Tc-99m agents to label eggs as the solid meal and compare to Tc-99m sulfur colloid (SC) for gastric emptying studies.Methods: In search of alternative agents for gastric emptying studies, we mixed and fried eggs with four different particulate compounds (Tc-99m labeled SC, tin colloid, nanocolloid and MAA), as well as with free pertechnetate and Tc-99m DTPA. We then measured the stability of these compounds in simulated gastric juice.Results: Our experiments demonstrated that in addition to Tc-99m sulfur colloid;Tc-99m MAA, Tc-99m nanocolloid and Tc-99m tin colloid also appear to make stable complexes with eggs in acidic environment.Conclusion: Therefore, these agents may be used for gastric emptying studies which could be more practical in routine conditions.Conflict of interest:None declared.
Highlights
Gastroparesis is a clinical syndrome characterized by delayed gastric emptying (GE) in the absence of mechanical gastric outlet obstruction
They concluded 99mTc-sulfur colloid (SC) binds better to egg whites compared with whole eggs, they state that stability of a radiolabeled solid test meal for gastric emptying studies must be established both for its constituents and for the method of preparation [7]
Gastric emptying with a solid test meal is the preferred method to assess gastric emptying in older children and adolescents
Summary
Gastroparesis is a clinical syndrome characterized by delayed gastric emptying (GE) in the absence of mechanical gastric outlet obstruction. Symptoms may include nausea, vomiting, early satiety, abdominal pain, and bloating. It is a condition of abnormal gastric motility, which presents with symptoms suggesting delayed GE in the absence of an anatomic obstruction. Gastric emptying scintigraphy (GES) is commonly performed to evaluate patients with symptoms that suggest an alteration of gastric emptying and/or motility [2]. The first use of radionuclides to measure GE was published in 1966 [2] Since it has become the standard for the measurement of gastric motility in clinical practice, because it provides a physiologic, noninvasive, and quantitative measurement of GE. As currently performed in most imaging centers, GES is limited to evaluation of a potential delay or acceleration in GE of a solid radiolabeled meal [3,4]. The aim of this study was to test alternative Tc-99m agents to label eggs as the solid meal and compare to Tc-99m sulfur colloid for gastric emptying studies
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