In vitro evaluation of magnetic fluid hyperthermia therapy on breast cancer cells using monodispersed Mn0.5Zn0.5Fe2O4 nanoflowers

Abstract

Magnetic fluid hyperthermia (MFH) is emerging as an alternate treatment therapy for cancer of different types, due to its potential low side effects and relatively less painless treatment option. However, the implementation of standalone therapy is still challenging and needs research to optimize the effective killing of 100% cancerous tissues, number of therapy sessions, time duration of the therapy, controlled hyperthermia window temperature, etc. We report here the potential of nanoclusters (nanoflowers) based dispersion and on an in vitro study on breast cancer cells (MDA-MB-231). The nanoclusters were characterized using XRD, TEM, DLS, VSM and MFH, before investigating them with breast cancer cells. The effect of MFH, before and after the treatment of induction heating on MDA-MB-231 cells, were also studied. Results show that the MFH is capable of killing almost 87% of cells within 30 min of treatment on cells in the presence of magnetic nanoclusters. This shows the potential of developing nanoflowers for the treatment of cancer over other single domain magnetic nanoparticles.