Abstract
Strategies to evaluate antioxidant and cytotoxic activity of pet ether extract of Artocarpus chama Buch. seedTaksim Ahmed, Mohammad Nasir Uddin, Md. Kamal Hossain, Md. Imamul Islam, Nizam Uddin, Md. Ehsanul Haque Mazumder
Highlights
Research interest in phytoceuticals to inhibit chronic diseases and aging is gathering momentum
We examined the antioxidant activity of crude pet ether and methanol extracts, employing various in vitro assay systems, such as the DPPH (1,1-diphenyl-2picrylhydrazyl) scavenging assay, cupric reducing antioxidant capacity, reducing power antioxidant capacity and determination of total phenolic and flavonoid content, in order to understand the usefulness of this plant as a functional food as well as in medicine
The method is based on the reduction of ethanolic DPPHsolution in the presence of a hydrogen donating antioxidant, due to the formation of the non-radical form DPPH-H by reaction
Summary
Research interest in phytoceuticals to inhibit chronic diseases and aging is gathering momentum. A number of natural compounds such as polyphenols and flavonoids have been reported as antioxidants, which entrap and deactivate damaging ROS and RNS (Pietta, 2000; Hossain et al, 2006). They possess antiinflammatory, antiviral and anticancer properties (Di Pietro et al, 2002; Barron et al, 2002). Two new stilbenes with two isoprenoid groups, namely artostilbenes A and B, were isolated from the stems of Artocarpus chama Buch (Yong-Hong et al, 2007). We examined the antioxidant activity of crude pet ether and methanol extracts, employing various in vitro assay systems, such as the DPPH (1,1-diphenyl-2picrylhydrazyl) scavenging assay, cupric reducing antioxidant capacity, reducing power antioxidant capacity and determination of total phenolic and flavonoid content, in order to understand the usefulness of this plant as a functional food as well as in medicine
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