Abstract
The in vitro antioxidant, cytotoxic and apoptotic activities of Teucrium ramosissimumextracts were investigated. The antioxidant activities of the tested extracts were evaluated through three chemical assays which are (1): The cupric reducing antioxidant capacity (CUPRAC), (2) The reducing power (RP) and (3) The ferric reducing antioxidant power (FRAP). Total oligomer flavonoids enriched extract (TOF) showed the best antioxidant activity evaluated by the CUPRAC and FRAP assays with trolox equivalent antioxidant capacity (TEAC) values of 12.85 and 0.525 µM, respectively compared to control. Whereasethyl acetate (EA) extract exhibited the highest reducing power when using the RP assay with a TEAC value of 2.025 µM. Furthermore, the effects of T. ramosissimum extracts on cell proliferation and induction of deoxyribonucleic acid (DNA) degradation, as an apoptotic marker in human leukemia cells were also examined. The cytotoxic activity revealed that the methanol extract inhibited significantly the proliferation of K562 cells (IC50 =150 µg/ml), however no specific DNA degradation indicating an apoptotic effect was observed. Key words: Teucrium ramosissimum, antioxidant activity, cytotoxic, apoptotic, K562 cells.
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