Abstract
Cancer is one of leading cause of death worldwide and sustained focus on development of novel anticancer agents from medicinal plants. Traditional medicinal systems are based on plant as a source of medicine for the treatment of chronic debilitating and life threatening disease and disorders. Annona reticulate Linn. is widely used in the traditional medicine for the treatment of various disease conditions. Methanolic leaves extract of Annona reticulata Linn. Was investigated for anticancer potential using sulforhodamine B (SRB) cytotoxicity assay against colon cancer (HCT15), Human lung cancer (Hop65) and Human hepatoma (HEPG2) cell lines. Adriamycin was used as a standard to compare the results. The extract exhibited anticancer effect against all the cell lines. The median growth inhibition (GI50) concentration for extract was <10 µg/ml against Human lung cancer and hepatoma cell line, showing moderate anticancer efficacy of methanolic extract against these cell lines. In conclusion, methanolic leaves extract of Annona reticulata Linn. Possess moderate anticancer activities in vitro which could be attributed to the presence of anticancerous phytochemicals like acetogenins.
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