Abstract
Alginate beads containing diclofenac hydroxyethylpyrrolidine were formulated with either Eudragit or chitosan in order to achieve an enteric formulation. In all cases, high entrapment efficiencies were obtained. The examination of fractured beads revealed an internal void in the Eudragit–alginate beads. In contrast, a dense homogeneous internal structure was observed in the chitosan–alginate beads due to interpolymeric complex. An interaction between chitosan and drug was also observed. Under conditions mimicking those in the stomach, a small amount of drug was released. The alginate–chitosan beads showed a release behaviour dependent on pH value and alginate–chitosan ratio.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
