In Vitro Degradation and In Vivo Skin sensitisation study of Hernia Mesh - Sterilized Partially Absorbable Tissue Separating Dual Layered Surgical Mesh

Abstract

As hernia mesh implants are used to reinforce the abdominal wall, several complications can occur, such as hernia recurrence, abdominal pain, seroma formation and infection, depending on their biocompatibility. The polymer coated knitted mesh is used to repair hernias by providing a flexible scaffold. The objective of this study was to assess skin sensitisation potential of polar and non-polar extract and In Vitro degradation and In Vivo skin sensitisation pattern for polymer coated knitted mesh. The guinea pig maximization test (GPMT) is usually performed with one moderately irritant induction dose of the allergen and gives a qualitative assessment hazard identification of the allergenicity of the chemical. The apparent morphological change, weight, and strength loss rate of the mesh all showed the degrading impact. The degradation of polymer coated knitted mesh is performed to check polymer layer pattern after implantation.