Abstract
Anodic aluminum oxide films modified by silver incorporation (Al-O-Ag) under specific electrodeposition conditions were produced and their biocompatibility was analyzed by in vitro assays using mammalian cell lines. The results obtained demonstrate that Al-O-Ag substrates are well tolerated by human dermal fibroblasts. The alumina pads doped with silver for short time-period (30 seconds) showed the highest biocompatibility among all modified metal substrates and in comparison with three dental alloys.
Highlights
IntroductionBy electrochemical processes layers of Al2O3 with desirable thickness can be produced on the surface of aluminum and its alloys, which are available on the market and have a reasonable price [3]
Aluminum oxide (Al2O3) is extensively used in medical devices manufacturing
Taking into account these considerations, the current study aimed to investigate the biocompatibility of anodic aluminum oxide with electrochemically embedded silver particles (Al-OAg)
Summary
By electrochemical processes layers of Al2O3 with desirable thickness can be produced on the surface of aluminum and its alloys, which are available on the market and have a reasonable price [3]. These oxide films are able to passivate the metal surface and do not allow any further interactions with the environment. Studies with different mammalian cell lines demonstrate that nanosized silver can exhibit toxicity to mouse lung, liver and stem cells, human and mouse fibroblasts, as well as human carcinoma cells [14] Taking into account these considerations, the current study aimed to investigate the biocompatibility of anodic aluminum oxide with electrochemically embedded silver particles (Al-OAg)
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