Abstract
The methanolic extract of Hemidesmus indicus (L) R.Br. (Asclepiadaceae) roots was found to inhibit lipid peroxidation and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 217.5 μg/ml. The concentrations needed to scavenge hydroxyl and superoxide radicals were 73.5 and 287.5 μg/ml, respectively. The intravenous administration of this extract (5 mg/kg body weight) in rabbits delayed the plasma recalcification time and enhanced the release of lipoprotein lipase enzyme significantly. The extract also inhibited ADP-induced platelet aggregation in vitro (50–250 μg), which was comparable to commercial heparin.
Published Version
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