Abstract
Microbial infection of the genital tract or semen is one of the leading causes of male infertility. Consequently, there is a need to seek alternative products from natural sources. The antibacterial, phytochemical and cytogenotoxicological assessments of the aqueous extract of Cymbopogon citratus leaf were evaluated. The antibacterial potential of the extract was done via agar-well diffusion and microdilution techniques. The phytochemical analysis was done via standard protocols.The cytogenotoxicity of the extract were analyzed using the Allium cepa assay. All test organisms were found to be sensitive to the extract except Pseudomonas. aeruginosa where no measurable zone of inhibition could be ascertained at all concentrations assessed.The highest mean inhibition diameter of 21.33±1.20mm against S. sapophyticus was recorded and a concentration-dependent susceptibility noticed. The phytochemical results revealed the presence of saponins, flavonoid, glycoside, steroids, terpenoid and alkaloids. The Alliumcepa root showed reduced mitotic indices following aconcentration-dependent increase in the extract.It can be said that the aqueous extract of C. citratus had inhibitory activities against the tested pathogenic organisms with relative anti-tumour potential. This study indicated, C. citratus could be a potential source for antibacterial compounds for the possible treatment of male reproductive related infections.
Highlights
Plants generally serve innumerable purposes and can be used in the form of food, textile and shelter, as medicine and in religious practices[1]
The highest zone of inhibition of 21 mm was recorded against Staphylococcus saprophyticus at a concentration of 50mg/ml, while the lowest of 2 mm was recorded against Proteus mirabilis at the concentration of 25mg/ml
It was observed that the extract had minimum inhibitory concentrations (MICs) of 1.56 mg/ml against Escherichia coli, Klebsiella pneumoniae and Staphylococcus saprophyticus, while at 3.13 mg/ml against Proteus mirabilis
Summary
Plants generally serve innumerable purposes and can be used in the form of food, textile and shelter, as medicine and in religious practices[1]. Medicinal plants are of abundant importance to the health of individuals and societies. The use of traditional medicines and medicinal plant in most countries as therapeutic agents had help in the maintenance of good health and production of local herbal drugs. Objectives: The antibacterial, phytochemical and cytogenotoxicological assessments of the aqueous extract of Cymbopogon citratus leaf were evaluated. The Alliumcepa root showed reduced mitotic indices following aconcentration-dependent increase in the extract.It can be said that the aqueous extract of C. citratus had inhibitory activities against the tested pathogenic organisms with relative anti-tumour potential. Conclusion: This study indicated, C. citratus could be a potential source for antibacterial compounds for the possible treatment of male reproductive related infections. In vitro antibacterial and cytogenotoxicological properties of the aqueous extract of Cymbopogon citratusStapf (DC) leaf.
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