Abstract
Thrombous formation inside the blood vessels obstructs blood flow through the circulatory system leading hypertension, stroke to the heart, anoxia and so on. The complete deprivation of oxygen and infarction is a mode of cell death. Crude biologicals and their components possessing anti-thrombotic activity have been reported before. This study was aimed to investigate thrombolytic activity of ethanol extracts of four traditionally used medicinal plants. For this an in-vitro thrombolytic study was carried out along with streptokinase, and ethanol was taken as reference standard and negative control, respectively. The ethanol extracts (5 μg/μl) of Alpinia conchigera, Lannea grandis, Aglaonema hookerianum and Tridax procumbens 24.50%, 13.31%, 11.18%, and 8.70% clot lysis, respectively. Among the extracts studied Alpinia conchigera showed significant percent of clot lysis (24.50%) with reference to streptokinase (81.08%). Preliminary chemical group identification revealed the presence of alkaloids, glycosides, steroids, terpenoids, tannins and reducing sugars important secondary metabolites. Key words: Crude extracts, streptokinase, thrombolytic, traditional medicine
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