Abstract

Introduction and Aim: Combinative action of medicinal plants has earned an important place in the herbal medicinal field. The combination therapeutics may provide higher activity against various diseases in a synergistic manner. In the present research work the ethanolic leaf extracts of Tridax procumbens and root extracts of Boerhavia diffusa were studied for the assessment of synergistic cardioprotective activity through animal model. Materials and Methods: Wistar male albino rats were treated with combinative ethanolic extract (150 +150 mg/kg BW) to isoproterenol-induced myocardial infarcted rats. Cardio-protection was investigated by estimating the activities of inflammatory markers like CRP, myeloperoxidase, homocysteine, xanthine oxidase and HMG CoA reductase in serum, plasma and tissue sample. Results: The activities of CRP in serum and tissue myeloperoxidase were significantly elevated in isoproterenol- induced rats. Parameters like plasma homocysteine, tissue xanthine oxidase and HMG CoA reductase of isoproterenol administered rats also showed significant elevation. Combinative ethanolic leaf extract of Tridax procumbens and root extracts of Boerhavia diffusa treatment showed a marked difference in the altered parameters by preventing myocardial necrosis. Conclusion: The present study concludes that co-treatment with ethanolic extract of Tridax procumbens and Boerhavia diffusa confirmed the protective and inhibitory effect against isoproterenol induced myocardial infarction and proved to be more beneficial. Keywords: Isoproterenol; myocardial infarction; Tridax procumbens; Boerhavia diffusa; ethanol extract.

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