In Vitro Anthelmintic Activity of Papaya (Carica papaya L.) Seed Tea Againts Gastrointestinal Trematodes in Cattle

Abstract

<em>The prevalence rate of trematodosis in cattle is increasing in Bali and Nusa Tenggara, affecting productivity, sale value, and medical expenses. Papaya seeds (Carica papaya </em>L.<em>) contained metabolite compounds that had the potential as an anthelmintic for cattle. This study aimed to determine the anthelmintic activity of papaya seed tea and the percentage of gastrointestinal trematodes (Paramphistomum </em>spp<em>.) mortality in cattle. Worms that were actively moving were divided into five groups and applied with some treatments: the negative control (0.9% (w/v) of NaCl solution); the positive control (10% (w/v) Albendazole); and three concentrations of papaya seed tea (2.5, 5, and 10% (w/v)). The death time of 100% Paramphistomum </em>spp<em>. for negative control occurred at the 300<sup>th</sup> minute, longer than the papaya seed tea treatment, which happened in the 180<sup>th</sup> minute at a concentration of 2.5% and 210<sup>th</sup> minutes at 5% and 10% (w/v). Time of death 100% of positive control treatment Albendazole 10% (w/v) was the fastest (30 minutes). The death time parameter of papaya seed tea at the three concentrations significantly differed from Albendazole 10% (w/v) (p<0.05). Therefore, papaya seed tea could potentially be used as an antitrematodal agent to control Paramphistomum </em>spp.<em> in cattle.</em>