Abstract
Garcinia husor is one of the folk medicines in Maluku-Indonesia. This species has been used for the treatmet of Malaria disease. The phytochemical contents and antiplasmodial activity not reported yet. In this study we evaluated the quantitative phytochemicals, in vitro and in vivo antiplasmodial activity of stem bark ethyl acetate extract. In vitro assay was done using P. falciparum 3D7 strain sensitive of chloroquine. For in vivo analysis, four groups of M. musculus were infected by P. berghei and their parasitemia levels were for 7 days of treatment with ethyl acetate extract; hematological and biochemical parameter were analyzed at the end of experiment. The result showed ethyl acetate extract with the TPC (169.47 mg GAE/100 g ±0.61) and TPC (167.37 mg QE/100 g ±1.05) was active against P. falciparum 3D7 strain (IC50 value of 0.31±0.43 μg/ml). The animal treated with extract showed suppression of parasitemia to 87.57±1.41% compared with the P. berghei infected-mice (negative control), ED50 value of 22.30 mg/kg BW. The dose of extract in 200 mg/kg BW was reduce parasitemia of infected mice with P. berghei more potential. The ethyl acetate of the stem bark G. husor with has antiplasmodial properties and future investigation are necessary to elucidate its mechanism of action.
Highlights
Malaria is a major infectious disease with a high mortality in the developing country (Boampong et al 2015)
Four groups of M. musculus were infected by P. berghei and their parasitemia levels were for 7 days of treatment with ethyl acetate extract; hematological and biochemical parameter were analyzed at the end of experiment
The results showed that an average percentage of inhibition against P. berghei of the infected only group (G1) and the infected treatment extract group (G2, G3, and G4) where the increased of dose treatment decrease percent growth of parasite
Summary
Malaria is a major infectious disease with a high mortality in the developing country (Boampong et al 2015). Efforts have been made to treat this disease related to the development of alternative antimalarial, due to the emergence of drug-resistant strain. Many plants are used therapeutically in alternative and traditional medicine to treat infectious diseases. New and safe antimalarial drugs are urgently needed and natural products can represent a vast source of leading molecules (Oliveira et al 2014). Garcinia species are known to contain phenolic compounds such as xanthones, benzophenones, flavones, and depsidone (Nilar et al 2005). Phenolic compounds showed that a wide range of biological
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