Abstract
In vitro and In vivo Anti-Arthritic and Anti-Inflammatory Activity of Bungarus Fasciatus Venom
Highlights
Inflammation, a body defence mechanism is triggered by several conditions including injury
1% of the world population is affected by rheumatoid arthritis [10]
Effect of Bungarus fasciatus venom (BFV) on serum proinflammatory cytokines: BFV significantly reduced serum pro inflammatory cytokines TNF-α, IL1β and IL-17 by 42.17%, 58.14% and 26.91% respectively; whereas standard drug, Indomethacin showed a reduction of TNF-α, IL-1β and IL-17 by 46.83%, 57.07% and 45.81% respectively when compared to arthritic control rats (Figure 2)
Summary
Inflammation, a body defence mechanism is triggered by several conditions including injury. Macrophages and articular cartilage itself produce of a variety of proinflammatory cytokines like TNF-α and IL-1β contributing to tissue destruction [7,8]. Rheumatoid arthritis, another form of inflammatory arthritis, involves chronic inflammation of the synovial membrane in the joints of hands and feet with subsequent cartilage and bone erosion and destruction [9]. 1% of the world population is affected by rheumatoid arthritis [10]. There are many anti-inflammatory drugs (NSAIDs) and antiarthritic drugs (DMARDs) that have wide applications in clinical conditions [11] and are associated with several side effects like G.I tract complications, ulcers, cardiovascular problems [12,13]. Alternative therapies from natural resources are ventured throughout the world
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