IN VITRO ACTIVITY OF VORICONAZOLE AGAINST YEAST AND FILAMENTOUS FUNGI, WHICH CAUSE BRONCHOPULMONARY AND DISSEMINATED MYCOSES IN TB PATIENTS

Abstract

We determined the sensitivity levels to voriconazole of clinical strains of yeasts of the genera Candida (14 species), Cryptococcus (3 species), Geotrichum (one species), Hanseniaspora (one species), Saccharomyces (one species), Saprochaete (one species), Rhodotorula (2 species), Trichosporon (one species) and of filamentous fungi of the genera Acremonium (one species), Alternaria (one species), Aspergillus (12 species), Aureobasidium (one species), Cladosporium (one species), Curvularia (one species), Fusarium (2 species), Paecilomyces (2 species), Penicillium (2 species), Rhizopus (one species), Trichoderma (2 species). Voriconazole activity was high against causative agent of candidiasis, cryptococcosis, aspergillosis, phaeohyphomycosis, rare yeast mycoses (most species), hyalohyphomycosis (most species) and was low against causative agent of rhodotorulosis (Rhodotorula spp.) and zygomycosis (Rhizopus arrhizus).