Abstract
Background: Diabetes has become one of the major burdens for developing country people mainly due to excessive cost and adverse effects of synthetic drugs. Plant-derived drugs in Bangladesh is currently being paid an emerging attention because of low cost and diverse floral distribution. This research investigated thein vitroα-amylase inhibitory and hypoglycemic activityof organic etracts of Phrynium imbricatumin normal and glucose induced hyperglycemic mice.Methods: Extracts were undertaken to measure in vitroα-amylase activity using starch-iodine method while the hypoglycemic effect was studied in glucose induced hyperglycemic mice.Results: All the extracts of P. imbricatum (EEPI) showed considerable α-amylase inhibitory activity and chloroform extract (CHPI) showed the highest activity among them as compared to Acarbose the reference antidiabetic drug.The extracts at 400 mg/kg and 800 mg/kg b.w. significantly (p < 0.05) reduced fasting glucose level in normal mice as compared to standard drug glibenclamide (5 mg/kg) but CHPI at 800 mg/kg showed the highest hypoglycemic effect decreasing 23.78 % of blood glucose level after 2 h of administration in normal mice, while glibenclamide decreased 49.30 %. In oral glucose tolerance test, at 400 mg/kg and 800 mg/kg of extracts significantly reduced blood glucose level (p < 0.05) at 30 min. Area under the curve (AUC) of the extracts were at the range of 12.895-14.258 hr.mmol/L., and 14.573 hr.mmol/L and 9.835 hr.mmol/L for control and glibenclamide respectively.Conclusion: The results demonstrate that Phrynium imbricatummay be a very remarkable source for the development of new oral antihyperglycemic agent.
Highlights
Diabetes is a metabolic disorder usually caused due to either complete or partial dysfunction of insulin secretion with or without varying degrees of insulin resistance [1]
Chloroform extract (CHPI) showed the highest inhibition and it’s half maximal inhibitory concentration (IC50) was found to be 2.504 ± 0.023 mg/ mL which is lower than others and statistically significant (p < 0.001) compared to that of standard antihyperglycemic agent of IC50 0.912 ± 0.015 mg/mL
The strength of α-amylase inhibitory actions of the extracts were graded as CHPI > Ethanol extract of P. imbricatum (EEPI) > Pet ether extract (PEPI)
Summary
Diabetes is a metabolic disorder usually caused due to either complete or partial dysfunction of insulin secretion with or without varying degrees of insulin resistance [1]. Several different medicinal plants and plant-derived drugs have been using for treating diabetes in traditional medicine system as well as in ethnomedicinal practices [6]. This is due to the lesser side effects, cost effective and availability of plant based drugs compared to the synthetic hypoglycemic agents [7] different plants have been reported to show α-amylase inhibitory activity and they may be relevant to the treatment of diabetes [5]. Diabetes has become one of the major burdens for developing country people mainly due to excessive cost and adverse effects of synthetic drugs. This research investigated the in vitro α-amylase inhibitory and hypoglycemic activity of organic etracts of Phrynium imbricatum in normal and glucose induced hyperglycemic mice
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