In situ modification on cellulose acetate hollow fiber membrane modified with phospholipid polymer for biomedical application

Abstract

The hollow fiber membrane (HFM) made from synthetic polymers need improvement in terms of hemocompatibility or biocompatibihty, for use in the medical field. In this study, cellulose acetate (CA) HFM modified with the water-soluble amphiphilic 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer (poly (MPC-co- n-butyl methacrylate) (PMB80, MPC:BMA = 80:20 (mol%)) was prepared by a dry-jet wet spinning process. The PMB80 was coated on the CA HFM surface in situ during the phase inversion of the dope solution by using a PMB80 solution as an inner coagulant. The CA/PMB80 coating HFM showed no physical structure changes in comparison with the CA HFM prepared using the same preparative conditions. The structure and permeability of the CA/PMB80 coating HFM was controllable by changing the preparative conditions. From the results of the X-ray photoelectron spectroscopic (XPS) observations, the amount of modification was changed with the concentration of PMB80 in the coagulant. The XPS signal attributed to the phosphorus atom of the PMB80 remained even after 1 month of rinsing with distilled water. Also, the CA/PMB80 coated HFM showed good permeability and a low membrane fouling property in comparison with the non-modified CA HFM, due to the low protein adsorption property of the PMB80.