Abstract
The development of in situ gel system has received considerable attention over the past few years. This interest has been sparked by advantages shown by in situ forming delivery system such as ease of administration and reduced frequency of administration, improved patient compliance and comfort. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation from which the drug gets released in a sustained and controlled manner. Various biodegradable polymers that are used for the formation of in situ gels include pectin, guar gum, carbopol, Xyloglucan, gellan gum, alginic acid, Xanthum gum, Chitosan, HPMC, Poloxamer etc. Mainly in situ gel administered by oral ocular, rectal, vaginal, injectable and intaperitoneal routes. The poor bioavailability conventional ophthalmic formulation is due to rapid precorneal drug loss there some statics and dynamic barriers which also affect the bioavailability drug. The ocular drug delivery system is considered as crucial and challenging as the delivery of drug is quite difficult.
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