Abstract
Owing to the adverse consequences of excess glucose (Glu) and hydrogen peroxide (H2O2) on humans, it is imperative to develop an electrochemical sensor for detection of these analytes with good selectivity and sensitivity. Herein, a nanohybrid comprising nickel cobaltite nanoparticles (NiCo2O4 NPs) embedded on conductive Ti3C2Tx nanosheets (NSs) has been prudently designed and employed for the electrochemical detection of Glu and H2O2. The developed nanohybrid has been systematically characterized using morphological and spectral techniques, and then immobilized on a glassy carbon electrode (GCE). Under optimized conditions, the developed NiCo2O4-Ti3C2Tx/GCE based electrochemical sensor has demonstrated an impressive analytical response towards Glu and H2O2 with good sensitivity and selectivity. The non-enzymatic sensor has demonstrated a broad linear range from 30 μM to 1.83 mM for Glu, and two linear ranges of 20-100 μM and 100 μM-2.01 mM for H2O2. The sensor has exhibited limits of detection (LOD) of 9 μM and 6 μM with sensitivities of 101.2 μA μM-1 cm-2 and 107.03 μA μM-1 cm-2, respectively, for Glu and H2O2 detection. The impressive analytical performance of the fabricated sensor in terms of linear range, LOD and sensitivity are ascribed to the (i) enhanced conductivity of Ti3C2Tx NSs, (ii) mediated electrocatalytic activity of NiCo2O4 NPs and (iii) large number of catalytically active sites on the NiCo2O4-Ti3C2Tx heterostructure. Notably, the NiCo2O4-Ti3C2Tx/GCE has demonstrated impressive stability and reproducibility, which is mainly due to the in situ uniform growth of NiCo2O4 NPs over Ti3C2Tx NSs.
Published Version
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