Abstract
Abstract: The present study experimentally investigated the nitro-substituted heteroaromatic carboxamidesas effective against PKnGof Mycobacterium tuberculosis. Here we designed 15 heteroaromatic carboxamides[A1-B5]. The activities of the compounds can be explained in terms of docking results and biological activity by ADMET prediction. Protein Kinase G is a thioredoxin-fold containing eukaryoticlike serine/threonine Protein Kinase is a virulence factor in Mycobacterium tuberculosis. In present study the compounds A7, A2, A5& A6 are the candidates that shows the good results in Molecular Docking and these are tested against the reference compound that is stand Anti-TB agent Isoniazid.
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