Research progress on related virulence factors of Mycobacterium tuberculosis

Abstract

During the long-term evolution of the host environment, Mycobacterium tuberculosis can completely or partially adapt to survive in the host cells by avoiding or modifying the host response to infection.Many factors contribute to the successful invasion of this pathogen into host cells.Over the past few decades, a great deal of researches have led to deeper understanding of the complex pathogenesis of Mycobacterium tuberculosis, especially its unique Ⅶ secretion system and the cell membrane with a variety of complex lipid have become the hot topic of the aspects.This review summarizes the recent research results of Mycobacterium tuberculosis associated virulence factors, hoping to find new drug targets from these virulence factors. Key words: Mycobacterium tuberculosis; Virulence-related factors; Virulence