IN SILICO ANALYSIS OF AN ARTICULAR CARTILAGE REGENERATIVE REHABILITATION UNDER CONDITIONS OF MESENCHYMAL STEM CELLS IMPLANTATION AND THEIR MECHANICAL STIMULATION

Abstract

One of the most important tasks of modern medicine is the development of effective technologies for the treatment of joint diseases caused by damage to the articular cartilage. The results of experimental studies and a number of successful clinical practices indicate that its solution can be found within the framework of a new medical direction - regenerative rehabilitation, which synergistically combines the methods of regenerative and rehabilitation medicine. In particular, regenerative rehabilitation of articular cartilage defects involves the use of cellular technologies, the effectiveness of which is enhanced by mechanical stimulation of chondrogenic cells, which accelerates their proliferation, differentiation, and formation of an extracellular matrix. The simulation results indicate that its outcome depends not only on a set of parameters determined by the state of the tissue in the defect aria, but also on their combination.One of the main goals of this work is to find the best combination of parameter values that are practically achievable in the process of articular cartilage regenerative rehabilitation using cellular technologies and mechanical stimulation of cells. Its solution is based on the study of a regenerative tissue rehabilitation mathematical model, the state parameters set of which is determined by the Sobol-Statnikov method, based on a systematic study of the parameter space uniformly distributed in a multidimensional cube. The practical significance of the results of the work lies in the fact that they can be used to evaluate the effectiveness of mechanical stimulation various methods of articular cartilage defects in the process of regenerative rehabilitation.