In Search of Benign Methodologies for Coordination: Synthesis, Characterization, and in vitro Biology of Transition Metal Complexes of N, N′-bis (salicylidine) toluene-2, 4-diamine with Binuclear Core

Abstract

A series of transition metal complexes of Zn(II), Co(II), Cu(II), Ni(II), and Mn(II) have been synthesized from Schiff's base H2Sal-2,4-toluene, [N,N′-bis(salicylidine)toluene-2,4-diamine] (IV) derived from salicylaldehyde and toluene 2,4-diamine using MORE technique. Structural features were obtained from FTIR, UV-VIS, molar conductance, ELEMENTAL analysis, 1H-NMR, mass spectral and X-ray diffraction studies, which have shown the formation of dimer complexes, where the ligand acts as a bridge between two metal cations. Ligand and complexes have been screened experimentally for their antimicrobial activity against different species of pathogenic bacteria; Viz., E. coli, S. aureus, B. subtilis and P. aureginosam and their antimicrobial potency have been discussed.