In-depth assessment of new Ti-based biocompatible materials

Abstract

The objective of the research is to obtain Ti20MoxSi (where x = 0, 0.5, 0.75, 1.0 wt %) alloys using the vacuum arc remelting (VAR) methods and to consider the effects of Mo and Si on physical-chemical, biological and mechanical biocompatibility. Through microstructure analysis the dendrites, grains, sub-grains, compounds have been confirmed; Mo adding determined the main β phase apparition and by increasing the Si content the dendritic microstructure was evidenced. The modulus of elasticity decreases with the amount of Si in the Ti20Mo alloys. The MTT assessment and fluorescent microscopy performed on fibroblasts and osteoblasts cells indicated a suitable cytocompatibility of the prepared alloys. Expression of osteopontin, metalloproteinases 2 and 9 (MMP2 and MMP9) in these areas into the periosteum and peri-implant highlight the bone mineralization. Mineralization and bone remodeling suggest a good biocompatibility of the implanted material with human tissue.