Abstract
This year marks the 100th anniversary of the publication of Anitschkow's classic paper proposing the central role of hypercholesterolemia in atherogenesis. We at the Journal of Lipid Research take this occasion to acknowledge the debt we all owe to Anitschkow and his colleagues for getting us on the right track. As discussed below in detail, his contributions were insightful and went well beyond simply pinpointing hypercholesterolemia as a major etiologic factor. Anitschkow's work led him to define most of the key elements in the initiation and evolution of lesions in animal models of atherogenesis.
Highlights
This year marks the 100th anniversary of the publication of Anitschkow’s classic paper proposing the central role of hypercholesterolemia in atherogenesis
It is difficult to believe that the key role of cholesterol in the pathogenesis of atherosclerosis was proposed 100 years ago! Yes, in 1913, Nikolai N
Anitschkow summarized the results of his pioneering work on the rabbit model of atherosclerosis in this way: The blood of such animals exhibits an enormous increase in cholesterin [cholesterol] content, which in some cases amounts to several times the normal quantity
Summary
This year marks the 100th anniversary of the publication of Anitschkow’s classic paper proposing the central role of hypercholesterolemia in atherogenesis. Anitschkow, a young Russian experimental pathologist in Saint Petersburg, reported that feeding rabbits a high-cholesterol diet produced arterial lesions that closely resembled those of human atherosclerosis [1,2,3]. Their blood cholesterol levels rose sharply, and within weeks their arteries began to show raised yellow lesions rich in “lipoids.” They exhibited structural features very much like those seen in the human disease.
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