Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis

Abstract

articlePhysiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesisF. B. Hillgartner, L. M. Salati, and A. G. GoodridgeF. B. Hillgartner, L. M. Salati, and A. G. GoodridgePublished Online:01 Jan 1995https://doi.org/10.1152/physrev.1995.75.1.47MoreSectionsPDF (9 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByFree Fatty Acid Receptors in Health and DiseaseIkuo Kimura, Atsuhiko Ichimura, Ryuji Ohue-Kitano, and Miki Igarashi30 October 2019 | Physiological Reviews, Vol. 100, No. 1Three-dimensional spheroid culture of adipose stromal vascular cells for studying adipogenesis in beef cattle22 February 2018 | animal, Vol. 12, No. 10Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways5 August 2018 | Nutrients, Vol. 10, No. 8Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity10 May 2018 | Hepatology, Vol. 68, No. 1Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, C/EBP-α via Akt signaling pathway and STZ-induced diabetic ratsBiomedicine & Pharmacotherapy, Vol. 103DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human PrimatesCell Metabolism, Vol. 27, No. 6Lipid Metabolism and Fatty Liver in Poultry30 June 2018 | Korean Journal of Poultry Science, Vol. 45, No. 2Association between FASN gene polymorphisms ultrasound carcass traits and intramuscular fat in Qinchuan cattleGene, Vol. 645Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice15 January 2018 | Journal of Lipid Research, Vol. 59, No. 3Effects of (−)‐hydroxycitric acid on lipid droplet accumulation in chicken embryos14 August 2017 | Animal Science Journal, Vol. 89, No. 1The influence of dietary fatty acid and fasting on the hepatic lipid metabolism of barramundi ( Lates calcarifer )27 October 2016 | Aquaculture Research, Vol. 48, No. 7Effects of nutrient intake level on mammary parenchyma growth and gene expression in crossbred (Holstein × Gyr) prepubertal heifersJournal of Dairy Science, Vol. 99, No. 12Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1cBiochemical and Biophysical Research Communications, Vol. 478, No. 3Identification of molecular candidates and interaction networks via integrative toxicogenomic analysis in a human cell line following low-dose exposure to the carcinogenic metals cadmium and nickel4 July 2013 | Oncology Reports, Vol. 30, No. 3Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and β-oxidation29 January 2013 | Biology, Vol. 2, No. 1Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoidsAnna M. D'souza, Jacqueline L. Beaudry, Andrei A. Szigiato, Stephen J. Trumble, Laelie A. Snook, Arend Bonen, Adria Giacca, and Michael C. Riddell15 April 2012 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 302, No. 8Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved regionMichael N. Davies, Brennon L. O'Callaghan, and Howard C. Towle1 October 2010 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 299, No. 4Liver and muscle metabolic changes induced by dietary energy content and genetic selection in rainbow trout (Oncorhynchus mykiss)C. Kolditz, M. Borthaire, N. Richard, G. Corraze, S. Panserat, C. Vachot, F. Lefèvre, and F. Médale1 April 2008 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 294, No. 4A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-α null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndromeHelen J. Atherton, Nigel J. Bailey, Wen Zhang, John Taylor, Hilary Major, John Shockcor, Kieran Clarke, and Julian L. Griffin1 October 2006 | Physiological Genomics, Vol. 27, No. 2Comparative Aspects of Lipid Metabolism: Impact on Contemporary Research and Use of Animal ModelsThe Journal of Nutrition, Vol. 135, No. 11Dietary Conjugated Linoleic Acid Affects Morphofunctional and Chemical Aspects of Subcutaneous Adipose Tissue in Heavy PigsThe Journal of Nutrition, Vol. 135, No. 6Starvation and Feeding a High-Carbohydrate, Low-Fat Diet Regulate the Expression Sterol Regulatory Element-Binding Protein-1 in ChickensThe Journal of Nutrition, Vol. 134, No. 9Nutritional Regulation of mRNA ProcessingThe Journal of Nutrition, Vol. 134, No. 9The subcellular localization of the ChoRE-binding protein, encoded by the Williams–Beuren syndrome critical region gene 14, is regulated by 14-3-326 May 2004 | Human Molecular Genetics, Vol. 13, No. 14n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms1 April 2004 | Journal of Lipid Research, Vol. 45, No. 7From The Cover: Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis26 April 2004 | Proceedings of the National Academy of Sciences, Vol. 101, No. 19Analysis of medium-chain acyl-coenzyme A esters in mouse tissues by liquid chromatography–electrospray ionization mass spectrometryAnalytical Biochemistry, Vol. 325, No. 2Alteration of urinary profiles of endogenous steroids and polyunsaturated fatty acids in thyroid cancerCancer Letters, Vol. 202, No. 2Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model24 September 2003 | The Prostate, Vol. 57, No. 3Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria16 August 2003 | Journal of Lipid Research, Vol. 44, No. 11Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects19 August 2003 | The Pharmacogenomics Journal, Vol. 3, No. 5I N V IVO M EASUREMENT OF F LUXES THROUGH M ETABOLIC P ATHWAYS : The Missing Link in Functional Genomics and Pharmaceutical ResearchAnnual Review of Nutrition, Vol. 23, No. 1Plant biotin-containing carboxylasesArchives of Biochemistry and Biophysics, Vol. 414, No. 2The adipose-tissue renin–angiotensin–aldosterone system: role in the metabolic syndrome?The International Journal of Biochemistry & Cell Biology, Vol. 35, No. 6Short- and long-term nutritional modulation of acetyl-CoA carboxylase activity in selected tissues of rainbow trout (Oncorhynchus mykiss)9 March 2007 | British Journal of Nutrition, Vol. 89, No. 06Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acidBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1631, No. 3Feed Restriction Significantly Alters Lipogenic Gene Expression in Broiler Breeder ChickensThe Journal of Nutrition, Vol. 133, No. 3Selective Proteolytic Processing of Rat Hepatic Sterol Regulatory Element Binding Protein-1 (SREBP-1) and SREBP–2 During Postnatal Development17 December 2002 | Journal of Biological Chemistry, Vol. 278, No. 9SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCα transcription in hepatocytes16 October 2002 | Journal of Lipid Research, Vol. 44, No. 2Seasonal variation in milk conjugated linoleic acid and Δ9-desaturase activity in dairy cowsLivestock Production Science, Vol. 79, No. 1Effects of dietary carbohydrate on the development of obesity in heterozygous Zucker ratsThe Journal of Nutritional Biochemistry, Vol. 14, No. 1Biliary lipid secretion, membrane pumps, and the metabolic response to fasting: Distinct PPAR-ts of a common regulatory pathwayGastroenterology, Vol. 124, No. 1Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes16 October 2002 | Journal of Lipid Research, Vol. 44, No. 1Starvation-induced posttranscriptional control of rat liver mitochondrial citrate carrier expressionBiochemical and Biophysical Research Communications, Vol. 299, No. 3Increased lipogenesis in isolated hepatocytes from cold-acclimated ducklingsE. Bedu, F. Chainier, B. Sibille, R. Meister, G. Dallevet, D. Garin, and C. Duchamp1 November 2002 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 283, No. 5Coordinate regulation of ovine adipose tissue gene expression by propionateJournal of Animal Science, Vol. 80, No. 11Inhibition of the Splicing of Glucose-6-phosphate Dehydrogenase Precursor mRNA by Polyunsaturated Fatty Acids18 June 2002 | Journal of Biological Chemistry, Vol. 277, No. 34Regulation of monocyte gene expression by the extracellular matrix and its functional implicationsImmunological Reviews, Vol. 186, No. 1Training down-regulates fatty acid synthase and body fat in obese Zucker ratsMedicine & Science in Sports & Exercise, Vol. 34, No. 7Inhibition of Endogenous Thyroid Hormone Receptor- β and Peroxisome Proliferator-Activated Receptor- α Activities by Humic Acid in a Human-Derived Liver Cell LineThyroid, Vol. 12, No. 5Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy statusHirohito Sone, Hitoshi Shimano, Yuki Sakakura, Noriyuki Inoue, Michiyo Amemiya-Kudo, Naoya Yahagi, Mitsujiro Osawa, Hiroaki Suzuki, Tomotaka Yokoo, Akimitsu Takahashi, Kaoruko Iida, Hideo Toyoshima, Atsushi Iwama, and Nobuhiro Yamada1 January 2002 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 282, No. 1Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolismChapter 6 Fatty acid synthesis in eukaryotesExercise Down-Regulates Hepatic Fatty Acid Synthase in Streptozotocin-Treated RatsThe Journal of Nutrition, Vol. 131, No. 9Global Expression Analysis of Extracellular Matrix–Integrin Interactions in MonocytesImmunity, Vol. 13, No. 6The Biology of Somatotropin in Adipose Tissue Growth and Nutrient PartitioningThe Journal of Nutrition, Vol. 130, No. 11Transcriptional regulation of the adipocyte fatty acid synthase gene by agouti: interaction with insulinKATE J. CLAYCOMBE, YANXIN WANG, BRYNN H. JONES, SUYEON KIM, WILLIAM O. WILKISON, MICHAEL B. ZEMEL, JOSEPH CHUN, and NAIMA MOUSTAID-MOUSSA8 September 2000 | Physiological Genomics, Vol. 3, No. 3Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob MiceMolecular Cell, Vol. 6, No. 1Exercise attenuates nuclear protein binding to gene regulatory sequences of hepatic fatty acid synthaseRussel Fiebig, Mitchell T. Gore, and Li Li Ji1 September 1999 | Journal of Applied Physiology, Vol. 87, No. 3Biochemical Basis of Oligofructose-Induced Hypolipidemia in Animal ModelsThe Journal of Nutrition, Vol. 129, No. 7A High Glycemic Index Starch Diet Affects Lipid Storage–Related Enzymes in Normal and to a Lesser Extent in Diabetic RatsThe Journal of Nutrition, Vol. 128, No. 11Insulin, Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Insulin-Like Growth Factor I as Putative Mediators of the Hypolipidemic Effect of Oligofructose in RatsThe Journal of Nutrition, Vol. 128, No. 7Insulin increases fatty acid synthase gene transcription in human adipocytesKate J. Claycombe, Brynn H. Jones, Melissa K. Standridge, Yingshi Guo, Joseph T. Chun, James W. Taylor, and Naïma Moustaïd-Moussa1 May 1998 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 274, No. 5Histidase Expression Is Regulated by Dietary Protein at the Pretranslational Level in Rat LiverThe Journal of Nutrition, Vol. 128, No. 5Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding proteinQianmei Li, Michael S. Chua, and Clay F. Semenkovich1 April 1998 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 274, No. 4Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytesF. Bradley Hillgartner, and Tina Charron1 March 1998 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 274, No. 3Biology of Somatotropin in Growth and Lactation of Domestic AnimalsTERRY D. ETHERTON, and DALE E. BAUMAN7 January 1998 | Physiological Reviews, Vol. 78, No. 3Lipoprotein Metabolism and Fattening in PoultryThe Journal of Nutrition, Vol. 127, No. 5Time-dependent effects of insulin on lipid synthesis in cultured fetal rat hepatocytes: A comparison between lipogenesis and glycogenesisMetabolism, Vol. 46, No. 4 More from this issue > Volume 75Issue 1January 1995Pages 47-76 Copyright & PermissionsCopyright © 1995 the American Physiological Societyhttps://doi.org/10.1152/physrev.1995.75.1.47PubMed7831398History Published online 1 January 1995 Published in print 1 January 1995 Metrics